Pharmacology and Toxicology

Objectives

By studying this subject, in addition to developing transversal skills, students are able to know the fundamental aspects of the properties and mechanisms of action of drugs from various pharmacological groups on which rational medicinal therapy is based, as well as their interactions and adverse reactions. You also learn to search for bibliography related to toxicological and pharmacological data of various chemical and biological compounds, and their application in the development of drugs. Finally, students acquire the skills to evaluate the pharmacological effectiveness and toxicity of certain drugs.

Learning outcomes

• RA1. Know the main toxic compounds and their mechanism of action.
• LO2. Shows skills for critical reflection in the processes linked to the exercise of the profession.
• LO3. Globally evaluates the learning processes carried out in accordance with the plans and objectives set and establishes measures for individual improvement.
• LO4. Analyzes specific knowledge of the field and contextualization in national and international environments.
• LO5. It applies procedures specific to scientific research to the development of training and professional activity.
• LO6. It ethically analyzes situations of injustice and inequality and proposes compensation measures.
• LO7. Shows an attitude of motivation and commitment to personal and professional improvement.
• LO8. Shows sensitivity for fair and equal professional practice from a gender perspective.
• RA9. Acquire and demonstrate advanced knowledge of the theoretical and practical aspects and working methodology in the field of biomedicine.
• RA10. It collects and interprets data and information on which it can base its conclusions, which include reflections on matters of a social, scientific or ethical nature in the field of biomedicine.

Skills

General skills

• Formulate hypotheses following the scientific method, with an ability to summarize and analyze information in a critical way in order to be able to solve problems.

Specific skills

• Formulate hypotheses and design experiments in the field of biomedical research.
• Have a systemic vision of the organism, in particular metabolic regulation and control and cell signaling, in order to respond to biomedical challenges.
• Identify the mechanisms of action of infectious agents, drugs and toxins, and their effects on the body.
• Promote, respect and apply the principles of bioethics in professional activity.
• Recognize endogenous and exogenous agents involved in the main groups of pathologies.

Basic skills

• Students have demonstrated knowledge and understanding in a field of study that builds on general secondary education with the support of advanced textbooks and knowledge of the latest advances in this field of study.
• Students have the ability to gather and interpret relevant data (usually within their field of study) in order to make judgments that include reflection on relevant social, scientific and ethical issues.

Core skills

• Develop strategies for promoting gender equality and equity for all.
• Interact in international contexts to transfer knowledge to current and emerging fields of professional development and research.
• Reflect critically on knowledge of all kinds, with a commitment to professional rigor and quality.
• Take control of one's learning process with a view to personal and professional growth and an all-round education.

Content

1. Basic principles of pharmacology
   1. Introduction to pharmacology and drug development
   2. Pharmacokinetics
   3. Pharmacodynamics
2. Basic principles of experimental pharmacology
   1. Introduction to current legislation
   2. anesthesia
   3. Pharmacogenomics and personalized medicine
3. Pharmaceutical industry
   1. Search and validation of new pharmacological targets: presentation of different strategies: chemical libraries, natural products and rational drug design
   2. Drug design: modeling and structure-activity (SAR) studies (structure and geometry of protein targets)
   3. Pharmacological screening (selection phases until obtaining the lead/candidate)
   4. Tools to evaluate pharmacological activity and efficacy
   5. Tools to evaluate pharmacokinetics and toxicokinetics: models in vitro to predict ADME, in vivo and PK-PD studies
   6. Tools to assess toxicity: exploratory, mechanistic and regulatory studies
   7. Evaluation of safety margins in different phases of the development of a drug. Calculation of the first dose to be administered in humans
4. Pharmacology of the nervous system
   1. Pharmacology of the autonomic nervous system
      1. Adrenergic receptor
      2. Cholinergic receptor (effects mediated by nicotinic receptors)
      3. Histamine receptor
      4. Dopaminergic receptor
   2. Pharmacology of the central nervous system
      1. Anxiolytics and hypnotics
      2. Antidepressants
      3. Antiepileptics
      4. Antiparkinsonians
      5. antipsychotics
      6. Drugs for Alzheimer's disease
5. Pharmacology of the respiratory system
6. Pharmacology of pain and inflammation
   1. Analgesics and opiate pain relievers, antipyretics and anti-inflammatories
7. Cardiovascular pharmacology
   1. diuretics
   2. Pharmacology of vascular tone (antihypertensives)
   3. Lipid-lowering agents
   4. Pharmacological regulation of cardiac function (antiarrhythmics, heart failure and antianginals)
8. Hypoglycemic and digestive pharmacology
   1. Insulin and non-insulin oral hypoglycemic drugs
   2. Antiemetic drugs
   3. Drugs that modulate intestinal motility
9. Endocrine pharmacology
   1. Contraceptives
   2. Corticosteroids
10. Anti-infective pharmacology
    1. Resistance to antibiotics

Evaluation

• Exams: 50%
  • Partial exam 1: 25%. Minimum grade of 4/10
  • Partial exam 2: 25%. Minimum grade of 4/10
  • Important: you need to get an average of 5 between the two exam tests to be able to average with the rest of the activities.
• Evaluable activities: 30%
  • Activity 1. Basic principles of pharmacology: 5% (group). Differences between generic and reference medicine, biosimilar/biological and ATC classification
  • Activity 2. Database research and drug development data interpretation: 10% (group activity)
  • Activity 3. Clinical case on pharmacology of the nervous system: 5% (group)
  • Activity 4. Clinical case of anti-diabetic pharmacology (interactions and dosage regimen of insulin): 5% (group)
  • Activity 5. Antimicrobial activity and antibiotic resistance: 5% (group)
• Internships: 20%
  • Organ bath: 5%
  • PyMOL: 5%
  • Analyzes of C elegans: 10%

Methodology

In this subject, there are theoretical sessions, workshops or tasks at the end of the blocks to integrate and put into practice the knowledge acquired. Likewise, practical sessions are also held to familiarize students with the preclinical research stages of drug development, either in the evaluation of the structure-activity relationship, or in the drug efficacy trial in animal models. Attendance at the practical sessions is compulsory, while it is recommended to actively follow the theory of the subject and actively participate in the discussions, assignments and workshops within the classroom.

Bibliography

Bibliography

• Ahmad, U. & Catala, A. (2020). Molecular pharmacology. Retrieved from https://directory.doabooks.org/handle/20.500.12854/67790
• Bespalov, A. (2020). Good Research Practice in Non-Clinical Pharmacology and Biomedicine. Retrieved from https://link.springer.com/book/10.1007/978-3-030-33656-
• Florez, J., Armijo, J.A., i Mediavilla, A. (2014). Farmacología humana (6 ed.). Barcelona: Elsevier.
• Harvey, R. A., Whalen, K. (2016). Farmacología (6 ed.). Madrid: Wolters Kluwer.
• Katzung, B.G. (2019). Farmacologia: básica y clínica (14 ed.). Madrid: McGraw-Hil.

Reading

Teachers will provide complementary bibliography and compulsory reading throughout the course via the Virtual Campus.